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2022 MLB odds, picks, bets for Wednesday, Sept. 21 from proven model: This four-way parlay pays almost 18-1

2022 MLB odds, picks, bets for Wednesday, Sept. 21 from proven model: This four-way parlay pays almost 18-1

Slugger Aaron Judge can tie the American League record for home runs in a single season when he and the New York Yankees (89-58) host the Pittsburgh Pirates (55-93) on Wednesday. Judge hit home run No. 60 on Tuesday, pulling him within one of the AL record of 61 set by Roger Maris in 1961. Judge and the Yankees face Pirates starter Roansy Contreras (5-4, 3.24 ERA). New York is a -292 favorite in the latest Yankees vs. Pirates odds from Caesars Sportsbook, while Pittsburgh is a +235 underdog. The over/under for runs scored is 7.5.

First pitch is set for 7:05 p.m. ET at Yankee Stadium in the Bronx. The game is one of 15 on the MLB schedule for Wednesday. Elsewhere in the majors, the CardinalsAlbert Pujols continues his pursuit of career home run No. 700, against the Padres, and the Guardians and White Sox square off in Chicago. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 321-272 on top-rated MLB money-line picks since the start of the 2021 season, returning more than $600 for $100 bettors during that span. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Wednesday. They all involve games at 6:40 p.m. ET or later, so there’s still time to get these MLB picks in. If you successfully parlay the picks, you’d be looking at a payout of almost 18-1. You can only see the model’s MLB picks at SportsLine

Top MLB picks today

After simulating every game on Wednesday 10,000 times, the model is high on the Royals (+122) to beat the Twins. Kansas City has won two of its last three games, including a 5-4 win over Minnesota on Tuesday. Meanwhile, the Twins have struggled over the last week, dropping five of their last six games.

MJ Melendez is swinging a hot bat for the Royals. Over his last six games, the 23-year-old from Florida is 7-of-24 with a home run, four RBI, seven runs scored and a robust .903 OPS. In the victory over Minnesota on Tuesday, he went 2-for-4 with a double and a two-run homer. See who else to back right here.

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