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MLB DFS: Best DraftKings and FanDuel daily Fantasy baseball picks, lineup advice for Wednesday, Sept. 21, 2022

MLB DFS: Best DraftKings and FanDuel daily Fantasy baseball picks, lineup advice for Wednesday, Sept. 21, 2022


The big-hitters in the Toronto Blue Jays lineup put up another strong offensive performance on Tuesday in an 18-11 win against the Philadelphia Phillies. The series between the two continues on Wednesday, and Blue Jays batters could be primed for another breakout when they face off against pitcher Zack Wheeler. Jays outfielder Teoscar Hernandez is one of the names that had a big day on Tuesday and could help MLB DFS lineups once again.

Toronto beat the Phillies 8-2 in July with Wheeler on the mound for Philadelphia, and Hernandez slammed a 404-foot home run off of him in the fourth inning. Second baseman Santiago Espinal was 2-for-4 in that July matchup, and popped an RBI single in Tuesday’s win as well. Before you make your MLB DFS picks for Wednesday, be sure to check out the MLB DFS advice, strategy and projections from SportsLine daily Fantasy expert Mike McClure.

McClure is a daily Fantasy pro who has won over $2 million in his career. And when it comes to daily Fantasy baseball, McClure is at his best. Recognized in the book “Fantasy Football (and Baseball) for Smart People: How to Turn Your Hobby into a Fortune” as a top MLB DFS player, McClure’s proprietary projection model simulates each game 10,000 times, taking factors such as matchups and recent results into account. This allows him to find the best values on every site.

On Tuesday, McClure highlighted Braves starting pitcher Charlie Morton as one of his top MLB DFS picks on DraftKings and FanDuel. The result: Morton struck out nine and gave up just one run in 5.1 innings pitched to pick up a win and return 27.8 points on DraftKings and 46 points on FanDuel. Anybody that included him in their lineups was well on the way to a profitable day.

Now, as the 2022 MLB season heads into its final stretch, McClure has locked in his top MLB daily Fantasy picks for Wednesday, September 21. Head to SportsLine now to see them.

McClure’s top MLB DFS picks for Wednesday, September 21, 2022

One of McClure’s top MLB DFS picks for Wednesday is Giants outfielder Joc Pederson who is listed at $5,100 on DraftKings and $2,700 on FanDuel. Pederson snapped a four-game hitless streak with an RBI single in San Francisco’s 10-7 win against Colorado on Tuesday. This season, Pederson is fourth on the team in total hits (90), and has 22 home runs with 64 RBI.

The Giants continue their series against Colorado on Wednesday and will face…

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